Autores: Gómez Gutiérrez Cristina, Manzano Robleda María del Carmen, Uribe Misael, Méndez Sánchez Nahum
Article commented Rockey DC, Vierling JM, Mantry P, Ghabril M, Brown Jr., RS, Alexeeva O, Zupanets IA, et al. For the HALT-HE Study Group.Randomized, doubleblind, controlled study of glycerol phenylbutyrate in hepatic encephalopathy. Hepatology 2014; 59: 1073-83. Comment Hepatic encephalopathy (HE) is a serious neuropsychiatric complication of both acute and chronic liver disease. Historically, the role of ammonia accumulation has dominated explanations of the pathogenesis of HE. However, evidence has emerged for a role of other concurrent factors such as inflammation, hyponatremia, neurosteroids, oxidative and nitrosative stress, manganese with cerebral edema.
2014-04-12 | 649 visitas | Evalua este artículo 0 valoraciones
Vol. 13 Núm.3. Mayo-Junio 2014 Pags. 409-411 Ann Hepatol 2014; 13(3)