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Staphylococcus aureus is one of the most common causes of bloodstream infections (BSI) and vancomycin has been used as the main therapy to treat methicillin-resistant S. aureus (MRSA) BSI. Although commercial methods are frequently used in clinical laboratories, some studies have shown that their minimum inhibitory concentrations (MIC) values are higher when compared to the broth microdilution (BMD) method, recommended by the Clinical and Laboratory Standards Institute (CLSI), which can lead to erroneous treatment. Besides, reduced MIC for vancomycin among clinical S. aureus isolates have already been reported. The present study aimed to verify the effectiveness of three different methods used to detect vancomycin MIC values in S. aureus isolates recovered from BSI collected in two hospitals in Rio de Janeiro, between January 2008 and July 2009.

Palabras clave: Bloodstream infections; Staphylococcus aureus; susceptibility methods; vancomycin.

2014-04-15   |   456 visitas   |   Evalua este artículo 0 valoraciones

Vol. 8 Núm.4. Abril 2014 Pags. 588-560 J Infect Developing Countries 2014; 8(4)