Resumen

Bleeding complications in dengue may occur irrespective of the presence of plasma leakage. We compared plasma levels of modulators of the endothelial barrier among three dengue groups: bleedings without plasma leakage, dengue hemorrhagic fever, and non-complicated dengue. The aim was to evaluate whether the presence of subtle alterations in microvascular permeability could be detected in bleeding patients. Plasma levels of VEGF-A and its soluble receptors were not associated with the occurrence of bleeding in patients without plasma leakage. These results provide additional rationale for considering bleeding as a complication independent of endothelial barrier breakdown, as proposed by the 2009 WHO classification.

Palabras clave: Dengue; bleeding tendency; VEGF.

2014-06-13   |   419 visitas   |   Evalua este artículo 0 valoraciones

Vol. 8 Núm.6. Junio 2014 Pags. 799-803 J Infect Developing Countries 2014; 8(6)