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CASE PRESENTATION A 23 year-old female at the time of diagnosis, had been previously evaluated at a different institution due to general malaise, early satiety, thrombocytosis and leukocytosis dependent on the granulocytic cellsin all stages of maturation. A bone marrow aspirate (BMA) was performed as well as a bone marrow biopsy (BMBx) and a bone marrow G band cytogenetic (GC) analysis. A balanced translocation between chromosomes 9 and 22 [t(9;22)] in 20 metaphases an alyzed established the diagnosis of Philadelphia chromosome positive (Ph+) chronic myeloid leukemia (CML) in chronic phase. She was initially treated intermittently with hydroxyurea, 3 g PO for leukocytosis control; the hematological response was irregular. However, since this approach does not affect the cytogenetic response in CML patients, interferon alpha (IFNα) and cytarabine were begun. She followed this treatment until it was changed back to hydroxyurea due to hematological relapse and a failed cytogenetic response.

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2014-11-06   |   305 visitas   |   Evalua este artículo 0 valoraciones

Vol. 64 Núm.2. Marzo-Abril 2012 Pags. 192-198 Rev Invest Clin 2012; 64(2-ENGLISH)