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Dear Editor: We read with interest the review of Mar Riveiro Barciela, et al. which shows that in developed countries a minority of acute hepatitis cases are attributed to Hepatitis E virus (HEV) infection and they are mainly undiagnosed. This review describes that infection by HEV has been related to extra hepatic manifestations, including neurological, renal, muscular and hematological disorders. These manifestations include inflammatory polyradiculopathy, Guillain-Barré syndrome, bilateral brachial neuritis, encephalitis, proximal ataxia, myopathy, membranoproliferative glomerulonephritis and relapses of IgA nephropathy. As in hepatitis A, HEV infection has been related to the haematological disorders such as severe thrombocytopenia and pure red cell aplasia. However, this concise review does not describe extra hepatic endocrine manifestations. Secondary thyroiditis to viral infections is wellknown but the association with viral hepatitis has only been reported in cases of infectious mononucleosis and hepatitis A. The association of acute hepatitis E, hepatitis B and thyrotoxicosis has been recently published as well as another case about autoimmune thyroiditis and HEV, but no cases of subacute thyroiditis have been reported. As it is known, both the T3 and T4 regulate the cells metabolism including the hepatocytes ones and then, in turn, the liver function. The liver is involved in the metabolism of thyroid hormones by regulating their systemic effects.

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2014-12-22   |   408 visitas   |   Evalua este artículo 0 valoraciones

Vol. 14 Núm.1. Enero-Febrero 2015 Pags. 141-142 Ann Hepatol 2015; 14(1)