Resumen

Introduction: The pattern of bleeding tendencies in dengue and its corellation with platelet count and other factors requires clarification. Methodology: A retrospective study on bleeding tendencies in adults with dengue and platelet counts of less than 100,000 per mm³ was conducted. Factors associated with bleeding were analyzed. The study cohort were grouped as dengue with severe thrombocytopenia when platelet count was < 50,000/mm³ and as dengue with moderate thrombocytopenia if platelet count was 50,000–100,000/mm³. Results: A total of 638 patients formed the study cohort. A 24.1% prevalence of bleeding tendencies was observed. Prior anti-platelet drug intake, platelet count of < 70,000/mm³, international normalized ratio > 2.0, and partial thromboplastin time > 60 seconds were associated with bleeding. Esophagogastroduodenoscopy was found to identify structural gastroduodenal lesions when dengue was complicated by hematemesis or melena. Conclusions: The results of this study suggest that bleeding complications in dengue can occur at platelet counts of up to 70,000/mm³, and that prior anti-platelet drug intake increases bleeding risk. Evaluation of hematemesis or melena in dengue with esophagogastroduodenoscopy is beneficial.

Palabras clave: Dengue; thrombocytopenia; bleeding; prevalence.

2015-01-22   |   415 visitas   |   Evalua este artículo 0 valoraciones

Vol. 9 Núm.1. Enero 2015 Pags. 105-110 J Infect Developing Countries 2015; 9(1)