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Multi-drug resistance has become a major threat to community acquired and nosocomial infections, worldwide. Carbapenems are used as last resort drugs because of the increasing resistance against beta-lactam group antibiotics. The resistance against the carbapenem antibiotic class has also emerged worldwide for at least a decade and became a major public health problem. The latest metallo-beta-lactamase (MBL) named New Delhi metallo-beta-lactamase (NDM-1) has been identified as a novel class of carbapenemase in Enterobacteriaceae. It was first identified in a Swedish patient who travelled to India to receive his treatment and was admitted to New Delhi hospital. This was the first report of bla_NDM-1 and the first report of MBL carriage among Enterobacteriaceae in UK. Subsequently, many reports on the emerging trends of NDM-1 in different parts of the world have been published. A total of ten variants of NDM (NDM-1 to NDM-9, NDM-12) have been reported so far. The hydrolytic activity against all â-lactam of NDM and its variants, except NDM-2, have been found increased as compared to NDM-1.

Palabras clave: NDM-1; migratory birds; drug resistance.

2015-01-22   |   307 visitas   |   Evalua este artículo 0 valoraciones

Vol. 9 Núm.1. Enero 2015 Pags. 120-121 J Infect Developing Countries 2015; 9(1)