Resumen

Type I interferons are potent cytokines that possess antiviral, immunomodulating and antiproliferative actions. The development of autoimmune hepatitis is a well recognized complication of treatment with alpha IFN in patients with chronic viral hepatitis. Yet, the occurrence in patients under treatment with beta IFN for other indications is controversial and its occurrence often underestimated. We report two cases of severe acute autoimmune hepatitis in two patients undergoing therapy with IFN beta 1a for multiple sclerosis who recovered under early immunosuppressive therapy.

Palabras clave: Autoimmunity liver failure hepatotoxicity early steroid treatment.

2015-02-04   |   418 visitas   |   Evalua este artículo 0 valoraciones

Vol. 14 Núm.2. Marzo-Abril 2015 Pags. 273-280 Ann Hepatol 2015; 14(2)