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Klebsiella pneumoniae is thought to be the most common species producing ESBLs, and almost 50% of Klebsiella pneumoniae isolates produce ESBL in some countries. Furthermore, antimicrobial co-resistance within ESBL-producing isolate communities limits the number of drugs that are effective against these strains, leaving carbapenems as the most reliable agents. Carbapenem resistance can arise through the production of acquired metallo-β-lactamases such as VIM and IMP or from production of non-metallo-carbapenemases of the IMI/NMC, SME, OXA, or KPC families. Resistance may also be due to a combination of impermeability caused by porin loss and ESBL or AmpC β-lactamase production. This impermeability was documented in several cases in which carbapenem-resistant K. pneumoniae emerged in vivo in response to ertapenem, meropenem, and less frequently to imipenem exposure.

Palabras clave: Ertapenem; ESBL; carbapenem; resistance; Klebsiella pneumoniae.

2015-02-28   |   407 visitas   |   Evalua este artículo 0 valoraciones

Vol. 9 Núm.2. Febrero 2015 Pags. 218-221 J Infect Developing Countries 2015; 9(2)