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Castiella A, et al. Liver iron concentration is not raised in patients with dysmetabolic hyperferritinemia In this issue of Annals of Hepatology, Castiella, et al. examined the relationship between liver iron concentration (LIC), hyperferritinemia and metabolic syndrome in a Spanish cohort of patients. Metabolic syndrome is defined by the presence of at least three of the following: obesity (increased waistline circumference), atherogenic dyslipidemia (hypertriglyceridemia and/or low high-density lipoprotein), hypertension or insulin resistance (elevated glucose levels or frank diabetes). Metabolic syndrome is increasing in prevalence in Western societies and is on the order of 25% of the adult population. Nonalcoholic fatty liver disease (NAFLD) is often observed in concert with metabolic syndrome with similar prevalence rates. Hyperferritinemia is commonly associated with both metabolic syndrome and NAFLD; a recent report from Chen, et al. found this association in the context of normal hepatic iron concentrations. However, this as well as other reports has been relatively limited in accuracy by the imaging and calculation methods for determining liver iron concentration (LIC). To date, there is conflicting evidence from large-scale randomized clinical trials regarding the clinical importance of treating iron overload in improving histologic or biochemical parameters in metabolic syndrome associated with hyperferritinemia as is commonly seen in NASH/NAFLD.

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2016-06-23   |   328 visitas   |   Evalua este artículo 0 valoraciones

Vol. 15 Núm.4. Julio-Agosto 2016 Pags. 460-462 Ann Hepatol 2016; 15(4)