Resumen

Introduction: Obesity correlates with nonalcoholic fatty liver disease (NAFLD) and occurs in 90 to 100% of severely obese individuals (body mass index [BMI] > 35 kg/m²). Coffee consumption (CC) has been associated with reduced progression of fibrosis in both hepatitis C infection and NAFLD; however, this topic is still under discussion when this liver disease affects severely obese individuals. Objective: To assess the association between CC, insulin resistance (IR) and histological NAFLD morbid obese patients. Material and methods: Cross-sectional study, including obese individuals undergoing bariatric surgery, liver biopsy and histological diagnosis between September 2013 and August 2014. The patients were classified into 3 groups according to their weekly CC: 0- 239.9 mL; 240-2099.9 mL and > 2100 mL. Results. A total of 112 obese individuals were included (BMI = 41.9 + 4.3 kg/m²), with a mean age of 34.7 + 7.4 years; 68.6% were women. CC was reported by 72.3% of patients. There were no statistical significant differences between groups regarding the presence of IR (84.8% vs. 74.2% vs. 75.9%; p = 0.536). Progressively higher percentages of individuals with normal liver histology were observed (14.7% vs. 21.9% vs. 24.3%). NASH (65.7% vs. 70.3% vs. 57.5%) were observed among those who consumed greater coffee volumes (p = 0.812). In conclusion, obese individuals with elevated CC exhibited lower frequencies of NASH, although with no statistical significance in this sample.

Palabras clave: NAFLD NASH insulin resistance coffee liver disease.

2016-06-24   |   197 visitas   |   Evalua este artículo 0 valoraciones

Vol. 15 Núm.3. Mayo-Junio 2016 Pags. 350-355 Ann Hepatol 2016; 15(3)