Resumen

Background and rationale: The post-Liver Transplant Quality of Life (pLTQ) questionnaire, developed in the United States, is a disease-targeted instrument designed to evaluate health-related quality of life (HRQoL) in liver transplant recipients. Our study sought to validate a version of the pLTQ for use in the Brazilian population. Translation and cross-cultural adaptation were carried out in accordance with international standard practices for questionnaire validation. Validity was measured by means of convergent validity (correlations between pLTQ domains and WHOQOL-Bref domains). Reliability was assessed by measurement of internal consistency (Cronbach’s alpha coefficient), reproducibility (intraclass correlation coefficient), sensitivity to change (effect size), and floor and ceiling effects. Results: The study sample comprised 160 liver transplant recipients, with a mean age of 56.9 + 10.4 years, treated at a tertiary hospital in Southern Brazil. The sample was largely male (62.5%), and the predominant indication for liver transplant was hepatocellular carcinoma (49.4%). Only two questionnaire items were modified during the translation and cross-cultural validation stage. The mean total pLTQ score was 5.58 +0.9, with < 20% floor/ceiling effect. Correlations between pLTQ and WHOQOL-Bref domains were acceptable (r = 0.37 - 0.40). For similar dimensions, the correlations between WHOQOL-Bref and pLTQ were statistically significant (p < 0.001). Cronbach’s alpha for the total score was 0.91 (95% CI 0.89 - 0.93), with a range of 0.51 to 0.77 across domains. Reproducibility was 0.90, and sensitivity to change was 0.84. Conclusion: In conclusion, the Brazilian Portuguese version of the pLTQ exhibited good psychometric performance, suggesting that it can be a useful tool in the Brazilian cultural context.

Palabras clave: Validation studies patient outcomes assessment outcome measure.

2016-06-24   |   243 visitas   |   Evalua este artículo 0 valoraciones

Vol. 15 Núm.3. Mayo-Junio 2016 Pags. 377-385 Ann Hepatol 2016; 15(3)