Resumen

Background and rational: Data on newer adipokines and interleukins in patients with nonalcoholic fatty liver disease (NAFLD)are inconclusive. The primary aim of this study was the evaluation of serum vaspin, resistin, retinol-binding protein (RBP)-4, inter-leukin (IL)-1α and IL-6 levels in NAFLD patients compared to matched controls, and their association with disease severity. Material and methods: Twenty-nine consecutively enrolled NAFLD patients with histologically confirmed nonalcoholic simple steatosis (SS; n = 15) or steatohepatitis (NASH; n = 14) and 25 matched controls without NAFLD were recruited. Serum vaspin, resistin,RBP-4, IL-1α and IL-6 and biochemical tests were measured. Results. Serum vaspin levels were lower and IL-6 levels higher in NASH patients than controls, but similar between controls and SS patients, or NASH and SS patients (vaspin, controls: 728.5 ±39.3; SS: 634.6 ± 63.7; NASH: 531.5 ± 52.0 pg/mL; p for trend 0.028; IL-6, controls: 1.5 ± 0.2; SS: 2.5 ± 0.6; NASH: 3.0 ± 0.6pg/mL; p for trend 0.032). However, after adjustment for body mass index or waist circumference, both vaspin and IL-6 did not re-main significantly different between groups. Resistin, RBP-4 and IL-1α were not statistically different between groups. None of the selected adipokines or interleukins could independently differentiate NAFLD fron SS, or patients with more severe fron less severe histological lesions. Conclusion: Lower circulating vaspin, but higher IL-6 levels were observed in NASH patients than controls, whereas resistin, RBP-4 and IL-1α levels were similar between groups. However, these differences did not remain robust after adjustment for body mass index or waist circumference.

Palabras clave: Adipokine cytokine insulin resistance nonalcoholic steatohepatitis steatosis.

2016-10-21   |   294 visitas   |   Evalua este artículo 0 valoraciones

Vol. 15 Núm.5. Septiembre-Octubre 2016 Pags. 705-714 Ann Hepatol 2016; 15(5)