Resumen

Primary sclerosing cholangitis (PSC) belongs to the most obscure liver diseases. Patients with progressive PSC require liver transplantation as only therapeutic option. Previously several HLA- and non-HLA-associated PSC risk variants have been discovered, however their involvement in the development of PSC seems to be minor in comparison to environmental determinants. Lately, variant rs853974 at the RSPO3 gene locus has been shown to modulate the course of PSC. Here we briefly discuss the phenotypes related to this polymorphism and propose alternative directions of research that might help to identify new genetic modifiers of PSC progression.

Palabras clave: Cholestasis liver transplantation RSPO3 stellate cells.

2017-12-13   |   390 visitas   |   Evalua este artículo 0 valoraciones

Vol. 16 Núm.6. Noviembre-Diciembre 2017 Pags. 830-831 Ann Hepatol 2017; 16(6)