Resumen

Drug induced liver injury is a common cause of acute liver failure (ALF). While most of these cases are due to dose dependent hepatotoxicity with acetaminophen, idiosyncratic drug-induced liver injury (DILI) is responsible for about 15% cases of ALF. Antibiotics are the most common cause of idiosyncratic DILI as well as DILI induced ALF. Etodolac is a selective cycloxygenase- 2 (COX -2) inhibitor non-steroidal anti-inflammatory drug used as an analgesic and anti-inflammatory in musculoskeletal diseases. Severe liver impairment is extremely rare. Till date, only 3 cases of ALF related to etodolac have been reported in the literature. Here we report two cases with a unique presentation of ALF occurring due to DILI caused by etodolac, as diagnosed by Roussel Uclaf Causality Assessment Method (RUCAM).

Palabras clave: Drug induced liver injury hepatotoxin liver failure liver transplantation hepatic encephalopathy.

2017-12-13   |   111 visitas   |   Evalua este artículo 0 valoraciones

Vol. 16 Núm.5. Septiembre-Octubre 2017 Pags. 818-821 Ann Hepatol 2017; 16(5)