Resumen

Context: Conflicting theories exist as to whether treatment with Selective Serotonin Reuptake Inhibitors (SSRIs) is related to weight changes. Even among those authors arguing a causal effect, it is not clear whether weight changes are caused by pharmaceutical mechanisms, changes in appetite characteristic of the disorders, or alterations in eating habits. Objective: The objective of this study was to determine which factors most contributed to body weight changes in outpatients in treatment with SSRIs. Methods: A retrospective cohort study with data from 572 outpatients was conducted in the Mexican National Institute of Psychiatry. Patients were divided into two groups: those who gained and those that maintained or lost weight during treatment. A logistic regression model was created to predict group membership. Results and Conclusions: The following variables resulted significant (p < 0.01): duration of treatment (weeks) OR = 1.027; paroxetine OR = 2.33; increased appetite OR = 3.29; and being overweight or obese at the beginning of the study OR = 0.60. This study demonstrated that, in a clinical setting, a combination of treatment duration, pharmaceutical mechanisms, symptoms, side effects, and baseline characteristics all contribute to weight changes in psychiatric patients undergoing SSRI treatment.

Palabras clave: serotonin uptake inhibitors body weight changes paroxetine fluoxetine weight gain psychiatry.

2018-10-30   |   387 visitas   |   Evalua este artículo 0 valoraciones

Vol. 5 Núm.3. Julio-Septiembre 2018 Pags. 104-114 Rev Mex Endocrinol Metabol Nut 2018; 5(3)