Approach to the frail older adults with advanced diffuse B-cell lymphoma:

A narrative review 

Autores: Carrera Alcívar Vanesa A, Fernández Freire Miguel Á, Escobar Morillo Adriana L, Tixi Ramírez Ricardo E


The progressive aging in human population entails a series of biological and socioeconomic consequences that force the development of new policies aimed to improve the quality of life of older adults. The study of the relationship between the immune response and cancer in its various stages is essential to enhance intervention options. The application of the Comprehensive Geriatric Assessment (CGA) can be of great help in guiding chemotherapy and targeted antineoplastic therapy regimens, to improve tolerance and effectiveness in patients suffering cancer, particularly in Diffuse large B-cell lymphoma (DLBCL). DLBCL is a potentially curable neoplastic disease in the majority of the affected population such as older, fragile and comorbid adults. Hence, it becomes crucial to perform CGA in these patients using mechanisms that guarantee a multidimensional diagnosis that includes cognitive-affective, functional, social, nutritional and clinical situation, to adequately stratify patients into risk groups and individualize their treatment.

Palabras clave: Older adult quality of life diffuse large B-cell lymphoma comprehensive geriatric assessment pronostic

2022-03-02   |   49 visitas   |   Evalua este artículo 0 valoraciones

Vol. 7 Núm.2. Julio-Diciembre 2021 Pags. 55-62 J Lat Am Geriatric Med 2021; 7(2)