Protective role of statins against sepsis complications in the context of geriatric syndromes

Autores: Barrientos Ávalos José R., García Lara Juan M.A., Díaz Ramos Julio A.

Resumen

Background: Sepsis complications in the elderly arise from factors such as comorbidities and malnutrition. The role of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) in mitigating these complications remains underexplored. Methods: We analyzed 2008-2011 data for sepsis patients aged 65+. Cases had sepsis complications; controls did not. Patients were matched 1:1 on several factors. The association between statin use and complications was examined using multivariate conditional logistic regression, adjusting for geriatric syndromes. Results: Of participants (average age 78.5; 55.7% female), 40% used statins. Statin intake before hospitalization was less common in cases (25.2% vs. 54.8%; p < 0.001). Regression showed an inverse association between statin use and sepsis complications, consistent even after geriatric syndrome adjustments (odds ratios 0.26; 95% confidence intervals 0.12-0.55, p < 0.001). Conclusion: Statins appear protective against sepsis complications in the elderly. However, due to study design and existing ambiguities, results should be interpreted cautiously. Further research is advocated.

Palabras clave: Sepsis complications geriatric syndrome 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins)

2024-02-07   |   15 visitas   |   Evalua este artículo 0 valoraciones

Vol. 9 Núm.2. Julio-Diciembre 2023 Pags. 56-60 J Lat Am Geriatric Med 2023; 9(2)