Could neutrophil-to-lymphocyte ratio predict the development of delirium in older adults with hip fracture? A pilot study

Autores: Sireno Ledezma Angélica L., González Galván Célica R., Quintanilla Flores Dania L., Torres Pérez Juan F., Peña Martínez Víctor M., Salinas Martínez Ricardo, Muñoz Diaz Ana C., et al

Resumen

Background: The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory biomarker. Objective: To evaluate if levels were associated with the development of delirium in older adults hospitalized for hip fracture. Methods: An observational, prospective, analytical pilot study was conducted. Forty participants ≥ 65 years old hospitalized for hip fractures were included. NLR levels were collected from the medical records during the first 24 h of admission of each patient and every 72 h. Results: Twelve participants had delirium. There was no significant difference in the NLR median value at admission in the delirium group versus the no-delirium group (p = 0.768). We found a significant age difference (p = 0.02), cognition (p = 0.004), and activities of daily living (p = 0.004) between groups. In univariate analysis, age ≥ 80 (odds ratio [OR]: 4.22; 95% confidence interval [CI]: 1.0-17.79; p = 0.05), cognitive impairment (OR: 27.0; 95% CI: 2.72-267.79; p = 0.005), and a Lawton and Brody test < 3 score (OR: 13.8; 95% CI: 2.71-7.12; p = 0.002) were associated with an increased risk of delirium. Conclusion: The association between the NLR value and the development of delirium was not observed, but advanced age, moderate/severe cognitive impairment, and decreased instrumental activities of daily living performance were associated with a higher risk of delirium in older adults hospitalized for hip fracture with an increased risk of delirium.

Palabras clave: Older adults neutrophil-to-lymphocyte ratio hip fracture

2024-06-18   |   42 visitas   |   Evalua este artículo 0 valoraciones

Vol. 10 Núm.1. Enero-Junio 2024 Pags. 010-018 J Lat Am Geriatric Med 2024; 10(1)