Fragmento

High dose GH A number of strategies have evolved in the last few years that attempt to increase height potential in growth retarded children who are in puberty. Since growth hormone (GH) production rates more than double during adolescence, the use of high-dose GH therapy has been studied in this period. In a randomized trial of conventional vs. high dose GH therapy for 36mo in GH deficient pubertal children we observed a significant increase in the adult height potential of the subjects in the high-dose group (net predicted height gain +4.9cm) as compared to conventional doses. This led to the US Food and Drug Administration approval of the use of higher GH doses in puberty in those kids most growth retarded during this period, or in those whose height potential is still quite limited and they are in puberty. GnRH analogues In addition, abundant data show that suppressing the production of sex steroidal hormones with gonadotropin hormone releasing hormone analogues (GnRHa) delays epiphyseal fusion and can ultimately render youngsters with precocious puberty taller than they would be otherwise. This strategy has now been tried not only in children with sexual precocity but in those with GHD that are in physiological puberty and even those with short stature not due to GHD with mixed results.

Palabras clave:

2006-10-12   |   1,951 visitas   |   Evalua este artículo 0 valoraciones

Vol. 4 Núm.1. Febrero 2006 Pags. 40-42 Rev Venez Endocrinol Metabol 2006; 4(1)