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Insulin resistance is a simple concept with complex ramifications. The notion that insulin action differs in different people and under different circumstances has been known for a considerable period of time. For example, it has long been recognized that young children with type 1 diabetes are “sensitive” to small changes in insulin dosage, while obese adults with type 2 diabetes may require huge doses of insulin to establish metabolic control. What is more recent is the finding that insulin action differs in a number of different and very common conditions and may in fact be a central contributor to the pathogenesis of some or all of these, including obesity, atherogenesis, type 2 diabetes, the metabolic syndrome, hypertension, hyperandrogenism, polycystic ovarian syndrome and perhaps some types of malignancy. The increasing burden of obesity and its complications has increasingly focused the spotlight on insulin resistance in recent years. Yet most of this attention has been paid to adults and much less to the consequences and causes of insulin resistance in children and teens. This is despite the fact that many of the adults disease associated with insulin resistance, such as obesity, type 2 diabetes, atherosclerosis, have their origins in childhood.

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2006-10-12   |   1,637 visitas   |   Evalua este artículo 0 valoraciones

Vol. 4 Núm.1. Febrero 2006 Pags. 45-46 Rev Venez Endocrinol Metabol 2006; 4(1)