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Growth hormone (GH), insulin-like growth factor I (IGF-I), sex steroids, and also insulin, all are potent anabolic hormones. They synergize to develop the full body composition and metabolic changes of puberty and have significant nutritional effects in vivo. Large bodies of data have accumulated which improve our understanding of these complex and dynamic interactions between hormones and nutrients resulting in an adolescent human. Some of these interactions, both in health and disease, are explored and updated in this clinical review. Growth and Bone Metabolism: Sex steroids are critical for a normal and timely pubertal growth spurt, and his effects are largely mediated by their impact on GH production. Androgens are anabolic agents in bone and are important in bone remodeling and ample evidence supports the concept that these effects are independent of aromatization to estrogens. Males continue to actively accrue bone mass even after the completion of linear growth, and peak bone mass in males is not achieved until their mid twenties.

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2006-10-12   |   1,658 visitas   |   1 valoraciones

Vol. 4 Núm.1. Febrero 2006 Pags. 47-50 Rev Venez Endocrinol Metabol 2006; 4(1)