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Supported by: NIH grants, and research support from Glaxo Smith Kline, Novartis, Avera and Lilly. Irritable bowel syndrome (IBS) is one of the most common “functional” syndromes seen by gastroenterologists and primary care providers with a prevalence up to 15% worldwide. IBS is characterized by chronically recurring lower abdominal pain and discomfort associated with alterations in bowel habits, and in the absence of detectable organic causes for the symptoms, IBS remains defined by symptom criteria. The syndrome has been divided according to predominant bowel habit into subgroups IBS-D (diarrhea), IBS-C (constipation) and IBS-M (mixed). The fact that IBS like most functional pain disorders share stress-sensitivity of symptoms, show a high degree of comorbidity with psychological symptoms (primarily anxiety and somatization) and psychiatric disorders (anxiety disorder, depression), and respond to CNS directed therapies (both psychological and pharmacological) point towards an important role of the CNS in the pathophysiology of these syndromes.

Palabras clave: Irritable bowel syndrome (IBS).

2007-09-04   |   1,020 visitas   |   Evalua este artículo 0 valoraciones

Vol. 72 Núm.2. Agosto 2007 Pags. 60-61 Rev Gastroenterol Mex 2007; 72(Supl. 1)