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Diabetes Mellitus Type 1 is a burdensome disease that requires constant vigilance to monitor blood glucose, adjust insulin doses by injection or by programmable devices such as insulin pumps and to integrate nutrition and exercise with the given doses of insulin so as to avoid both hypoglycemia and hyperglycemia. The ability to predict this disease before all of the insulin secretory cells have been destroyed by the autoimmune process that is the cause of type 1 diabetes would be of clinical benefit. Hence, the rationale is that prediction before the appearance of clinical features and symptoms may allow intervention to preserve beta cell function. This ideal is supported by a host of intervention studies in animal models, especially the non-obese diabetic (NOD) mouse. In this species, a variety of interventions have been successful. However, in human beings, no interventions to date have been proven to demonstrate long term success.

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2008-12-05   |   874 visitas   |   Evalua este artículo 0 valoraciones

Vol. 6 Núm.1. Enero 2008 Pags. 17-18 Rev Venez Endocrinol Metabol 2008; 6(1)