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In the past a minority of children with congenital hypothyroidism (CH) were clinically detected. The diagnosis, nowadays, is based on neonatal screening and the confirmation of the disorder obtained by measuring plasma TSH and T4. Measurement of plasma thyroglobulin, thyroid US and scintigraphy are useful for a better classification of the disease. Plasma T4 and T3 as well as bone X ray of the knee are good indicators of the severity of fetal hypothyroidism. The incidence of CH is quite stable across countries and is about 1:3 000 to 4 000 newborns with the exception of African American population where the incidence is around 1:10 000 newborns. It is well known that this disorder is sporadic but there are also familial forms in about 2% of the cases.This observation is strongly in favour of a genetic contribution to developmental anomalies of the thyroid gland.

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2008-12-05   |   764 visitas   |   Evalua este artículo 0 valoraciones

Vol. 6 Núm.1. Enero 2008 Pags. 39-40 Rev Venez Endocrinol Metabol 2008; 6(1)