Resumen

Dam methylation is an essential factor involved in the virulence of an increasing number of bacterial pathogens including Salmonella enterica. Lack of Dam methylation causes severe attenuation in animal models. It has been proposed that dysregulation of Dam activity is potentially a general strategy for the generation of vaccines against bacterial pathogens. In this review, we focus our attention on the role of methylation by Dam protein in regulating bacterial gene expression and virulence in Salmonella enterica.

Palabras clave: DNA adenine methylase pathogenesis salmonella enterica.

2009-12-23   |   555 visitas   |   Evalua este artículo 0 valoraciones

Vol. 3 Núm.7. Agosto 2009 Pags. 484-490. J Infect Developing Countries 2009; 3(7)