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Even when there is no doubt that the clinical practice is personalized, when we consider the specific bio-psycho-social sphere for each patient, in recent times the term personalized medicine has been applied to the use of molecular data to predict the predisposition of a person to disease and to improve and individualize their treatment and follow-up, allowing also the development of new target-directed drugs. Evidence-based medicine has revolutionized the medical practice in the last 50 years by using a deductive process supported by scientific research to treat patients. The data derived from large studies provide the opportunity to establish significative associations that, due to their own characteristics, do not guarantee the absolute applicability to all patients, since the human being is not a biologically uniform entity. For these reasons, and taking advantage in the human genome mapping, in recent years a great effort has been made to measure the human variation and to use it to characterize the individual predisposition to disease and therapy response (the so-called predictive medicine). The discussion of most aspects of human variation is a delicate issue for most societies. Even when the genetic differences between human beings are fewer that those observed in other primates, it is clear that are sufficient and important for determining the susceptibility to disease and the response to drug therapy.

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2010-06-15   |   536 visitas   |   Evalua este artículo 0 valoraciones

Vol. 61 Núm.6. Noviembre-Diciembre 2009 Pags. 454-455 Rev Invest Clin 2009; 61(6-ENGLISH)