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Article commented: Porepa L, Ray JG, Sanchez-Romeu MP, Booth GL. Newly diagnosed diabetes mellitus as a risk factor for serious liver disease. CMAJ 2010; DOI:10.1503/cmaj.092144. Original Abstract Background. The negative impact of diabetes mellitus is well recognized, yet little is known about the effect of this disease on the liver, an organ susceptible to nonalcoholic fatty liver disease related to insulin resistance. We evaluated whether adults with newly diagnosed diabetes were at increased risk of serious liver disease. Methods. We used administrative health databases for the province of Ontario (1994-2006) to perform a population based matched retrospective cohort study. The exposed group comprised 438 069 adults with newly diagnosed diabetes. The unexposed comparison group- those without known diabetes-consisted of 2 059 708 individuals, matched 5:1 to exposed persons, by birth year, sex and local health region. We excluded individuals with preexisting liver or alcohol-related disease. The primary study outcome was the subsequent development of serious liver disease, namely, liver cirrhosis, liver failure and its sequelae, or receipt of a liver transplant.

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2010-07-19   |   805 visitas   |   Evalua este artículo 0 valoraciones

Vol. 9 Núm.3. Julio-Septiembre 2010 Pags. 307-309 Ann Hepatol 2010; 9(3)