Resumen

Introduction: There are several experimental model of acute lung injury induced by oleic acid (OA); however, there are few studies that show how this injury develops. Objective: This study seeks to detail the x-ray, hemodynamic, gasometrical, gravimetrical, macroscopic and microscopic alterations developed in an experimental model of canine OA induced acute lung injury (ALI). Material and methods: Twelve dogs were divided in 2 study groups: Group I (n = 6): Control group without ALI. Group II (n = 6); OA-induced ALI. All dogs were submited to X-ray, hemodynamic and gasometric evaluation before ALI induction, and later every 15 minutes during 150 minutes. At the end of the study, the animals were euthanatized and were evaluated the changes gravimetric, macroscopic and microscopic in injured lungs. Results: All the animals survived through the study. In group II, 100% of the animals developed X-ray (p < 0.003 Wilcoxon), hemodynamic, gasometrical and gravimetric (p < 0.5 ANOVA, Tukey), macroscopically and microscopically (p < 0.001 Wilcoxon) ALI. Conclusions: The OA-induced ALI is a model in which dogs develop X-ray, hemodynamic, gasometrical, gravimetrical, macroscopically and microscopically injuries of the exudative phase that lung with ALI injury presents.

Palabras clave: Acute lung injury oleic acid.

2010-10-07   |   744 visitas   |   Evalua este artículo 0 valoraciones

Vol. 62 Núm.3. Mayo-Junio 2010 Pags. 222-230 Rev Invest Clin 2010; 62(3-ENGLISH)