Resumen

Objective: To evaluate a possible association between urinary leukotriene E₄ (LTE₄) concentrations and airway resistance values before and after salbutamol inhalation in children with bronchopulmonary dysplasia (BPD). Material and methods: Children with BPD were cross-sectionally studied to measure airway resistance by the interrupter technique (Rint), before and after inhaling 200 μg salbutamol, and to quantify urinary LTE₄ levels by immunoassay. Results: Thirty one children with BPD (15 females) aged between 3 months and 9 years were studied. Our results showed that LTE₄ did not correlate with Rint values (r = 0.12, p = 0.52) even after adjusting by gender, atopy history, steroid use, and gastroesophageal reflux. Likewise, LTE₄ did not correlate with the degree of the airway response to salbutamol (r = -0.13, p = 0.50). A strong inverse association between age and Rint (r = .0.58, p < 0.001) was observed. Conclusion: We concluded that urinary LTE₄ did not correlate with airway resistance or with the response to a bronchodilator drug in children with BPD, suggesting that leukotrienes are not involved in airway obstruction in this disease.

Palabras clave: Bronchopulmonary dysplasia airway resistance urinary LTE₄.

2010-10-07   |   618 visitas   |   Evalua este artículo 0 valoraciones

Vol. 62 Núm.1. Enero-Febrero 2010 Pags. 15-22 Rev Invest Clin 2010; 62(1-ENGLISH)