Resumen

Introduction: Scarce data are available on Group A Streptococcus (GAS) antibiotic resistance in South America. Methodology: The antibiotic susceptibility patterns of GAS recovered from symptomatic children living in the central part of Brazil during a prospective epidemiological study were analyzed. Results: No isolates were resistant to penicillin or macrolides. Sixty-one percent of the isolates were highly resistant to tetracycline, of which 85% harboured the tetM resistance gene. Ninety-five percent of these tetracycline resistant isolates were also resistant to minocycline. Thirty different emm-types were associated with tetracycline resistance. Phylogenetic analysis indicates that tetracycline resistance arose independently in distantly related emm-types. Conclusions: A high level of GAS tetracycline resistance has been observed in the central part of Brazil due to the polyclonal dissemination of resistant emm-types.

Palabras clave: Tetracycline resistance minocycline resistance emm gene GAS phylogeny.

2011-04-19   |   340 visitas   |   Evalua este artículo 0 valoraciones

Vol. 4 Núm.11. Noviembre 2010 Pags. 704-711. J Infect Developing Countries 2010; 4(11)