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Pseudomonas putida colonizes several niches including soil, fresh water, and animal surfaces. Although rarely isolated from human infections, metallo-beta-lactamase (MBL)-containing P. putida clinical strains resistant to most beta-lactams) have recently been described and proposed to act as likely reservoirs of MBL genes. This, in addition to the lack of an effective clinical inhibitor of these metallo-enzymes, poses a serious challenge to antimicrobial therapy. bla_VIM-2 represents the most widely distributed MBL gene worldwide, and is most generally present in class 1 integrons [4,5, Pasteran F et al. (2005) 45th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Abstract C2 108/151]. These elements may be contained within transposons, and the whole arrangement subjected in turn to rapid spread among different bacterial species by the aid of wide-range plasmids. It follows that the elucidation of the genetic platform(s) in which bla_VIM-2 genes are contained enables us to rationally speculate on how they evolve and disseminate. We report here the identification for the first time of an unusual class 1 integron carrying bla_VIM-2 and aacA4 aminoglycoside acetyl transferase gene cassettes embedded in a complete Tn402-like transposon, all elements carried in turn by a self-transferable plasmid present in a carbapenem-resistant P. putida clinical strain. A P. putida strain, hereafter referred

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2011-04-21   |   414 visitas   |   Evalua este artículo 0 valoraciones

Vol. 4 Núm.6. Junio 2010 Pags. 412-416. J Infect Developing Countries 2010; 4(6)