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Pharmacokinetics of acemetacin and its active metabolite indomethacin in rats during acute hepatic damage and liver regeneration by Chávez-Piña, et al. The aim of this study was to examine the pharmacokinetics of acemetacin and of its active metabolite, indomethacin, during the necrotic and regenerative processes occurring after the induction of acute hepatitis by CCl₄ in the rat, a widely accepted experimental model of liver damage. They found that one day after CCl4 administration, liver necrosis was apparent and there was an increase in the circulating levels of indicators of liver damage and regeneration with regard to control conditions. By day 3, histological analysis revealed liver recovery, although not complete, while biochemical indicators of hepatic damage had reverted either totally or partially. Markers of liver regeneration were still increased. Bioavailability acemetacin and indomethacin was comparable to control values. The authors concluded that indomethacin bioavailability after oral administration of its precursor, acemetacin, is significantly reduced by acute hepatitis produced by CCl4. Pharmacokinetic alterations, as liver damage, are reversible, but do not require complete liver regeneration to return to basal conditions.

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2011-07-13   |   511 visitas   |   Evalua este artículo 0 valoraciones

Vol. 8 Núm.2. Abril-Junio 2009 Pags. 88 Ann Hepatol 2009; 8(2)