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1. IS IT USED PROPERLY METHOTREXATE IN RHEUMATOID ARTHRITIS CLINICAL TRIALS? Pseudónimo: Finzenú Introduction: A systematic review and an international committee recommended that doses of methotrexate 25 to 30 mg weekly are effective in controlling rheumatoid arthritis. It presents a systematic review to assess compliance with the recommendations. Materials and methods: We reviewed randomized controlled trials published in the last 5 years in PubMed, SciELO and Google Scholar, which evaluated methotrexate alone or in combination with other biological DMARs in adults with rheumatoid arthritis. Using the keywords: treatment, rheumatoid arthritis, methotrexate, biologic therapy. We excluded those not reference the dose used. Results: 24 clinical trials achieved the search criteria, a total of 9578 patients. The analysis of the frequency, mean statistically normal distribution measures. The average frequency of initial dose was 11.03 ± 4.46 mg, 17.27 final dose ± 6.07 mg. 66.6% of cases had initial dose equal to or less than 10 mg and 25% of the final dose was greater than or equal to 20 mg. Conclusion: The recommended dose of methotrexate in treating rheumatoid arthritis in published clinical trials are not used appropriately, 2 thirds of the studies did not initiate the appropriate doses and only a quarter come to final doses recommended. The authors suggest following the guidelines in the protocols of future studies.

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2012-01-12   |   426 visitas   |   Evalua este artículo 0 valoraciones

Vol. 18 Núm.5. Agosto 2011 Pags. 98-100 Rev. Colomb. Reumatol. 2011; 18(Supl. 1)