Resumen

Introduction: A retrospective cohort study on Salmonella-associated diseases (SADs) was conducted in 14 public hospitals across Lagos State, Nigeria, between 1999 and 2008. Methodology: Medical records of clinically diagnosed patients with confirmed Salmonella infections were reviewed for the 10-year period. Laboratory diagnosis of typhoid fever cases in all the hospitals were first based on Widal agglutination tests then followed by culture, while non-typhoidal Salmonella infections were based on culture technique. Results: A total of 85,187 confirmed cases of SADs were found, of which 880 deaths were recorded (case-fatality rate = 1.03%/10 years). The mean incidence of SADs in Lagos State for the 10-year period was estimated at 45 cases per 100,000 persons/year, while that of typhoid fever alone was 16 cases per 100,000 persons/year. During the studied period, the number of deaths due to typhoid fever was significantly (P < 0.05) higher than deaths due to gastroenteritis except in 2003 and 2004. Risk associated with typhoidal deaths was 4 to 11 times greater when compared to gastroenteritis deaths between 2000 and 2002. Salmonella-associated diseases were most prevalent in adults 21 – to30 years of age (49.49%). Cases of patients with invasive Salmonella-associated gastroenteritis were observed mainly in children under five years of age. Conclusion:

Palabras clave: Salmonella diseases retrospective typhoid fever gastroenteritis medical records.

2012-05-30   |   693 visitas   |   Evalua este artículo 0 valoraciones

Vol. 6 Núm.5. Mayo 2012 Pags. 387-395 J Infect Developing Countries 2012; 6(5)