Resumen

Quinolone resistance in Enterobacteriaceae is typically mediated by chromosomal mutations leading to alterations in the target enzymes DNA gyrase and topoisomerase IV, or changes in drug entry and efflux. However, three plasmid-mediated quinolone resistance (PMQR) mechanisms conferring decreased susceptibility to quinolones (including some fluoroquinolones) have been recently described: QepA and OqxAB effluxes, Aac(6´)-Ib-cr aminoglycoside acetyltransferase and Qnr proteins (qnrA, qnrB, qnrC, qnrD and qnrS). Although plasmid-mediated quinolone resistance of Qnr type has been identified in Enterobacteriaceae fron the United States, Europe, and Asia, little is known about the diversity, type or range of qnr genes in Latin America, especially in Venezuela. Therefore, the objective of this study was to screen for the presence of PMQR genes in non-typhoidal Salmonella enteric (NTS) strains with reduced susceptibility to fluoroquinolones, fron clinical samples and chicken meat in Venezuela.

Palabras clave: qnrB19 Salmonella Venezuela.

2012-05-30   |   561 visitas   |   Evalua este artículo 0 valoraciones

Vol. 6 Núm.5. Mayo 2012 Pags. 462-464 J Infect Developing Countries 2012; 6(5)