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Serum cystatin C: a non-invasive marker of liver fibrosis or of current liver fibrogenesis in chronic hepatitis C? Ladero, et al. Progression of fibrosis is an important prognostic factor in chronic hepatitis C. Factors associated with accelerated fibrosis include age at infection, alcohol consumption and co-infection with either HIV or hepatitis B. To determine level of fibrosis, liver biopsy has been considered the gold standard for many years. It is not a perfect test, however, as sampling error and interobserver variation have been observed. Additionally, there is a risk of bleeding, pneumothorax and biliary peritonitis when performed percutaneously, which is lowered when performed with the transjugular approach. With this in mind, various non-invasive tests, including serum markers and transient elastography, have been studied as possible alternatives to liver biopsy. No single test has proven superior, but results have been improved when used in combination, leading to the development of various diagnostic algorithms to assess liver fibrosis.

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2012-08-21   |   458 visitas   |   Evalua este artículo 0 valoraciones

Vol. 11 Núm.5. Septiembre-Octubre 2012 Pags. 615-617 Ann Hepatol 2012; 11(5)