Resumen

Introduction: Hepatitis B virus (HBV) infection in hemodialysis (HD) patients is a major concern, but limited information exists on the HBV genotyping in patients on maintenance HD in Turkey. Aim: To investigate the genotype and subgenotype distribution of HBV in Turkish HD patients with chronic hepatitis B. Material and methods: A total of 248 HBsAg positive patients undergoing long-term HD from all regions of Turkey were included in this study. HBV genotypes were determined by phylogenetic analysis and by genotyping tools. Results: HBV DNA was detected in 94/248 (38%) of the patients. Among the study patients, genotype D of HBV was predominant (99%) and one patient (1%) was infected with genotype G. The majority (82%) of HBV genotype D branched into subgenotype D1, and also in ayw2 HBsAg subtype clusters in the phylogenetic tree. However, 10% and 8% of the strains branched into subgenotype D2 (also in ayw3 HBsAg subtype cluster) and subgenotype D3 clusters, respectively. Conclusion: In conclusion, HBV genotyping should be routinely applied to HD patients to establish a baseline. Determination of genotypes/subgenotypes of HBV may provide robust epidemiological data related to their circulation as well as their transmissibility.

Palabras clave: Sequence analysis viral infection chronic liver diseases.

2012-11-14   |   619 visitas   |   Evalua este artículo 0 valoraciones

Vol. 11 Núm.6. Noviembre-Diciembre 2012 Pags. 849-854 Ann Hepatol 2012; 11(6)