Resumen

Clindamycin is a lincosamide antibiotic used in staphylococcal infections. It is an attractive option for clinicians because it is available for parenteral and oral use, distributes well in tissues, and is highly bacteriostatic against Staphylococcus aureus. However, the detection of its three resistance phenotypes (sensitive, resistant, inducible resistance) is crucial to guide antimicrobial therapy. Standard disk diffusion and broth microdilution fail to detect inducible clindamycin resistance. Clinical and Laboratory Standards Institute (CLSI) recommends the double disk diffusion test (D-test) to detect the presence of inducible clindamycin resistance. Also, the incidence of clindamycin resistance varies with geographic area and therefore local statistics are crucial to guide empiric therapy. We undertook a retrospective study to estimate the incidence of inducible and constitutive clindamycin resistance in our hospital.

Palabras clave: Clindamycin resistance; Staphylococcus aureus; D-test.

2013-01-23   |   293 visitas   |   Evalua este artículo 0 valoraciones

Vol. 5 Núm.4. Abril 2011 Pags. 316-317 J Infect Developing Countries 2011; 5(4)