Resumen

Introduction: We investigated the frequency of H274Y-positive swine-origin 2009 A (H1N1) influenza virus outbreak in Thailand during May-August 2009. Methodology: This study sought to find Oseltamivir resistance mutation H274Y by using pyrosequencing. Results: From 8,710 real-time RT-PCR swine-origin 2009 A(H1N1) influenza virus-positive specimens, 100 randomly selected samples identified one such virus with H274Y mutation using pyrosequencing. Conclusions: The patient probably acquired oseltamivir resistance from natural variation, since he had never received that form of treatment before and recovered from influenza-like symptoms without using anti-influenza drugs.

Palabras clave: H274Y; oseltamivir; Influenza A (H1N1); pyrosequencing.

2013-02-05   |   331 visitas   |   Evalua este artículo 0 valoraciones

Vol. 5 Núm.5. Mayo 2011 Pags. 348-352 J Infect Developing Countries 2011; 5(5)