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Resistance to fluoroquinolones (FQs) is relatively uncommon in Salmonella spp. when compared to other genera of the Enterobacteriaceae. However, the number of clinical isolates with reduced susceptibility to FQs has increased in recent years. These isolates with reduced susceptibility to FQs are linked to chromosomal mutations and other mechanisms, such as efflux pump, change in permeability of the membrane, or plasmid-mediated quinolone resistance (PMQR). To date, at least four types of PMQR genes are known, including the qnr genes (A, B, C, D, S, VC), the aac(6’)-Ib-cr gene, oqxAB gene, and the qepA gene. Quinolones are used in poultry production, and poultry products are frequently related to salmonellosis outbreaks in Brazil. Nonetheless, it was unknown whether PMQR determinants were present in Salmonella strains isolated in outbreaks. The aim of this study was to investigate the presence of PMQR by qnr and aac(6´)-Ib genes in 126 Salmonella enterica strains isolated from poultry origin (n = 12), from patients (n = 46), and foods (n = 68) related to outbreaks that occurred between 1999 and 2007 in Parana state, Brazil.

Palabras clave: Quinolone resistance; qnrA1; qnrB19; Salmonella.

2013-02-06   |   353 visitas   |   Evalua este artículo 0 valoraciones

Vol. 5 Núm.6. Junio 2011 Pags. 496-498 J Infect Developing Countries 2011; 5(6)