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A Canadian national retrospective chart review comparing the long term effect of cyclosporine vs. tacrolimus on clinical outcomes in patients with post-liver transplantation hepatitis C virus infection Yoshida, et al. Compared in a retrospective Canadian multicenter study cyclosporine with tacrolimus treatments regarding sustained virologic response and clinical outcomes in patients undergoing interferon-based treatment after liver transplantation due to HCV liver cirrhosis. The study cohort consisted of finally 458 patients derived from 5 transplantation centers and was confined to HCV RNA positive liver transplant recipients who received a transplant 3 to 13 years prior to the study initiation (1996-2006) in order to allow for an adequate duration of follow-up. Patients undergoing interferon-based treatment taking cyclosporine have significantly better odds (OR: 2.59, p = 0.043) of presenting a sustained viral response (67%) compared to tacrolimus (53%). This was not associated with a significant effect on post-liver transplantation clinical events including HCV-related deaths, graft loss, fibrosing cholestatic hepatitis, hepatocellular carcinoma, or graft rejection. The recommendation was given for further prospective longitudinal studies to assess the long term effect of immunosuppressive choices on the clinical outcomes in liver transplant recipients with HCV infection.

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2013-03-13   |   466 visitas   |   Evalua este artículo 0 valoraciones

Vol. 12 Núm.2. Marzo-Abril 2013 Pags. 170-172 Ann Hepatol 2013; 12(2)