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Article commented Van der Meer AJ, Veldt BJ, Feld JJ, Wedemeyer H, Dufour JF, Lammert F, Duarte-Rojo A, et al. Association between sustained virological response and all-cause mortality among patient with chronic hepatitis C and advanced hepatic fibrosis. JAMA 2012; 308: 2584-93. COMMENTS In the current commented article, van der Meer, et al. demonstrated that sustained virological response in patients with advanced fibrosis was associated with lower overall mortality, lower liver-related mortality including liver failure and liver cancer. No patient achieving sustained virological response required liver transplantation and liver-related mortality was more than 15 times lower (30 vs. 2%). Hepatocellular carcinoma rate was also reduced in comparison with non-responders but a significant risk remained. Cumulative HCC occurrence was 5.1% at 10 years vs. 21.8% in non-SVR. Genotype 3a, type 2 diabetes mellitus, older age, male gender, heavy alcohol consumption and histological cirrhosis were associated with increased risk of liver cancer.

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2013-03-13   |   609 visitas   |   Evalua este artículo 0 valoraciones

Vol. 12 Núm.2. Marzo-Abril 2013 Pags. 341-342 Ann Hepatol 2013; 12(2)