Resumen

Introduction The Acinetobacter spp. have emerged as important nosocomial pathogens worldwide. Most Acinetobacter spp are multidrug resistant and able to persist in the hospital environment thus causing serious hospital-acquired infections. Typing methods can distinguish outbreak strains from epidemiologically unrelated strains thus facilitating the institution of infection control measures. Phenotypic typing systems have largely been replaced by a number of molecular typing methods, namely ribotyping, pulsed field gel electrophoresis (PFGE), amplified fragment length polymorphisim (AFLP) analysis, random amplification of polymorphic DNA (RAPD), among others. However, inter-laboratory exchange of data for global epidemiological analysis is not possible with these methods. Multi locus sequence typing (MLST) alleviates this problem by offering the possibility of inter-laboratory transfer of data and comparison of results via the internet. MLST is a highly discriminative method for typing microorganisms and has been applied successfully for the epidemiologic characterization of a variety of bacterial pathogens. The Acinetobacter baumannii MLST Databases hosted at the Department of Zoology, University of Oxford website (http://pubmlst.org/abaumannii/) contain 596 Acinetobacter baumanii isolates from all over the world. However, Indian data on sequence types are not available. The aim of the present study was to type clinical isolates of Acinetobacter baumanii collected from hospitals in Delhi, India and compare them with isolates across the globe using MLST.

Palabras clave: Acinetobacter baumanii; MLST; ST; India.

2013-04-22   |   389 visitas   |   Evalua este artículo 0 valoraciones

Vol. 7 Núm.4. Abril 2013 Pags. 358-360 J Infect Developing Countries 2013; 7(4)