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In the 80´s Holliday and then Mammen described hereditary platelet hyperreactivity and called it Sticky Platelet Syndrome. Hyperreactivity was defined in the laboratory by detection of platelet aggregation with concentrations of agonists (ADP and/or epinephrine) that are lower than those used in the routine laboratory. SPS was described as type I, II, or III, based on the agonist to which platelets overreacted (both ADP and epinephrine, ADP alone, or epinephrine alone, respectively). In his description of SPS, Mammen emphasized the distinction between acquired platelet hyperaggregability and SPS, which he considered an inherited, autosomal dominant disorder. Interestingly, he described both arterial and venous thrombosis as being associated with this platelet phenotype, and suggested that aspirin could be used to prevent further thrombosis.

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2013-07-05   |   581 visitas   |   Evalua este artículo 0 valoraciones

Vol. 12 Núm.2. Abril-Junio 2011 Pags. 55-56 Rev Hematol 2011; 12(2)