Fragmento

HTLV-1 causes ATLL and HAM/TSP. The 3’end of the viral genome encodes the p12, p8, p13, p30, and HBZ proteins whose functions are not fully understood. We focused on the function of the p8 protein. Expression of the singly spliced orf-I mRNA yields the endoplasmic reticulum (ER) resident precursor p12 protein. Removal of an ER retention/retrieval signal located at the amino terminus of p12 yields the p8 protein, which traffics to the cell surface. The p12 and p8 proteins exert contrasting effects on T-cells.

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2013-07-08   |   427 visitas   |   1 valoraciones

Vol. 12 Núm.1. Abril-Mayo 2011 Pags. S22 Rev Hematol 2011; 12(Supl. 1)