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Genetic factors affecting susceptibility to alcoholic liver disease in an Indian population Kumar DA. Alcoholic liver disease (ALD) results from a complex interaction between behavioral, environmental, and genetic factors. Although several studies have defined a close relationship between cumulative alcohol intake and risk of developing liver damage, extensive individual variability exists in disease susceptibility. Even among heavy drinkers (more that 100 g alcohol per day), only some individuals develop clinical, biochemical, and histological signs of ALD, ranging from 5-40% in the different series. The importance of genetic factors in the predisposition to ALD has long been recognized.

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2014-03-01   |   311 visitas   |   1 valoraciones

Vol. 12 Núm.6. Noviembre-Diciembre 2013 Pags. 860 Ann Hepatol 2013; 12(6)